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Table of Contents

Overview
Patient Presents
History
Physical Examination
Laboratory Findings
Differential Diagnosis
Etiology
Pathophysiology
Hospital Progress Report
Types of TTP
Interfering Substances
Treatment and Management
Morbidity / Mortality
Quiz
References

Authors:

Ihab Abumuhor, BS, MT (ASCP)

Ellen Hope Kearns, MS, SH(ASCP)H

Division of Health Sciences, School of Health, California State University Dominguez Hills, Carson, CA
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Thrombotic Thrombocytopenic Purpura

Interfering Substances


Many drugs could affect the platelet count. Table 6 lists some of the drugs that reduce platelet counts or impair platelet function.

Table 6: Select group of interfering substances that adversely affect platelet quantity and platelet function
Interfering Substances that Adversely Affect Platelet Quantity Interfering Substances that Affect Platelet Function
Cardiovascular drugs: Digoxin, Quinidine Aspirin
Psychotrophic drugs: Tricyclics Aspartame
Infections: Ampicillin, Cephalosporins Heparin
High blood pressure: Furosmide, Clorthalidone Vitamin E
Heartburn: Ranitidine, Zantac, Pepcid Garlic/onions
Inflammation / Pain: aspirin, morphine Ginkgo biloba
Seizures: Valproic acid, Phenytoin Grape juice, red wine, raisins
Tuberculosis: Isoniazid Omega 3 fatty acids
Diabetes: Chlorpropamide Ticlopidine
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Next: Treatment and Management

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Last Update: August 29 2006